凝血和纤溶功能检测在重症急性胰腺炎中的意义

目的探讨凝血和纤溶功能检测对于重症急性胰腺炎的临床意义。方法将62例急性胰腺炎患者分为轻症急性胰腺炎(MAP,n=34)和重症急性胰腺炎(SAP,n=28)两组,另选择26例健康正常人作为正常对照组(NC),测定其血浆凝血酶原时间(PT)、凝血酶原时间国际标准化比率(INR)、纤维蛋白原(FIB)和D-二聚体(D-D)浓度,记录患者48h Ranson评分。结果 MAP组与NC组比较差异无显著性(P>0.05),而SAP组血浆PT、INR,FIB和D-D含量与MAP组和NC组比较差异有显著性(P<0.05)。MAP组上述指标与48hRanson分值无直线相关关系(P>0.05),而SAP组上述指标与48hRanson分值呈显著正相关(P<0.05)。结论监测凝血和纤溶功能变化对于重症急性胰腺炎病情评估和指导治疗有一定价值。

Objective To explore the clinical significance of detected coagulation and fibrinolysis function in sever acute pancreatitis（SAP） Methods 62 patients with acute pancreatitis（AP） were divided into mild AP（MAP） group（34 cases） and SAP group（28 cases）,and 26 normal people as the control group（NC）.Plasma concentration of the prothrombin time（PT）,international normalized ratio（INR）,fibrinogen（FIB） and D-dimer（D-D） were detected,and the result of 48 hour Ranson score was recorded in patients with AP.Results There was no statistical difference between MAP group and NC group（P0.05）,while Plasma concentration of the PT,INR,FIB and D-D in SAP group were significant different compared with MAP group and NC group（P0.05）.The was no significant correlation between PT,INR,FIB,D-D and Ranson score in MAP group（P0.05）,while the correlation between PT、INR、FIB、D-D and Ranson score in SAP group was significant（P0.05）.Conclusion Detected change of the coagulation and fibrinolysis function can reflect the severity of SAP and is of some value in the treatment of SAP.