摘要
目的探讨周围血中ＮＫ细胞、Ｔ细胞亚群、细胞膜白细胞介素－２受体（ｍＩＬ－２Ｒ）阳性细胞与重症肌无力（ＭＧ）发病及临床疗效的关系。方法用流式细胞仪计数３９例ＭＧ患者ＣＤ３、ＣＤ４、ＣＤ８、ＣＤ２５和ＣＤ５６抗体阳性细胞的百分率，应用许氏临床评分法对病情的严重程度和转归进行评定。结果ＭＧ患者的ｍＩＬ－２Ｒ（ＣＤ２５）阳性细胞无明显改变。ＣＤ３阳性细胞在肾上腺皮素激素治疗前、后无明显改变。ＮＫ细胞（ＣＤ５６）和ＣＤ４阳性细胞在治疗前均明显高于正常（Ｐ＜００１），治疗２个月后均明显下降（Ｐ＜０．０１，０．０５）。ＣＤ８阳性细胞治疗前后明显降低和增高（Ｐ＜００５）。结论ｍＩＬ－２Ｒ阳性细胞百分率不能直接反映ＭＧ的免疫功能紊乱，并对ＮＫ细胞和Ｔ细胞亚群的变化无直接调节作用。ＮＫ细胞增高，可能为其功能下降的代偿性变化。ＣＤ４增高，ＣＤ８下降提示免疫功能紊乱，符合自身免疫性疾病的特点。
Objective To investigate whether mIL-2R ,NK cell, and T-cell subsets
were related to pathogenesis and therapeutic efficacy of MG. Mathods\ CD 3,CD 4,CD 8,CD
25 and CD 56 from the peripheral blood were tested by flow cytometry in 39 MG patients
before and after treatment with adrenal corticosteroid(ACS) and in 20 healthy volunteers.The
clinical severity and prognosis of MG were evaluated by Xu's clinical scoring system. Results
There were no significant change in the percentages of mIL-2R and CD3 in MG patients. The
percentages of NK cell and CD4 cell were higher in MG patients than that of controls( P< 0.01)
before treatment,and decreased sigificantly (p<0.05) after treatment.CD8 was significantly( P
<0 05) decreased and increased respectively before and after treatment. The clinical efficiency
of ACS treatment was 79.49% (in 31 MG patients). Conclusions The results demonstrated that
variation of mIL-2R positive cell didn’t directly correlated with the disturbance of immune
function in patients with MG,and it might not directly regulate the changes of NK cells and T-cell
subsets.The increase in percentage of NK cells was perhaps a compensative change of their
functional decrease. CD4 increase and CD8 decrease might reflect the disturbance of
immunological function in patients with MG.It was consistent with the characteristics of
autoimmune diseases.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1999年第2期85-87,共3页
Chinese Journal of Nervous and Mental Diseases
