银杏叶注射液对实验性大鼠局灶性脑缺血的保护作用

Beneficial Effects of Ginkgo Bilboa Injection on Experimental Focal Cerebral Ischemia in Rats

以行为障碍、脑梗死范围、脑含水量、脑组织病理改变为观察指标，研究银杏叶注射液（ＧＢＥ）对大鼠大脑中动脉闭塞所致局部脑缺血的防治作用。结果表明，ＧＢＥ２０、４０ｍｇ／ｋｇ静脉注射可显著降低大鼠脑梗死范围和脑含水量，改善行为障碍。脑组织形态学检查显示，ＧＢＥ４０ｍｇ／ｋｇ组动物脑组织缺血病变较轻。提示ＧＢＥ对局灶性脑缺血具有保护作用。

Ginkgo bilboa injection, is extracted from ginkgo leaf. The protective effects of ginkgo bilboa extract (GBE) on focal cerebral ischemic injury were studied. Focal cerebral ischemia was produced by permanent occlusion of the proximal portion of the right middle cerebral artery (MCA) with the technique of Tamura. The neurologic status of each rat was carefully evaluated at 8 and 24 h after surgery. The cerebral infarction and water content were measured. The histological changes of brain tissue after MCAO in rats were also studied. Treatment with GBE 20 or 40 mg/kg iv was shown to significantly reduce the cerebral infarction and water content, attenuate neurological deficits. The degree of inhibition of cerebral infarction were 24.4% ( P <0.05 ) and 34.7% ( P <0.01 ), respectively. In pathological examination, the extent of tissue ischemia in the group of treatment with GBE 40 mg/kg was much less than that of control. These results indicate that GBE protects rats from ischemic neurological damage.