5,10-亚甲基四氢叶酸还原酶基因多态性与肺癌的相关性研究

Association Between Methylenetetrahydrofolate Reductase Genetic Polymorphisms and Risk of Lung Cancer

叶酸代谢在肺癌发生过程中占有重要的地位,因为叶酸的代谢同时影响了DNA与核苷酸的合成。5,10-亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)是一种非常重要的叶酸还原酶,它不可逆地将5,10-亚甲基四氢叶酸催化生成5-甲基四氢叶酸,而后者正是同型半胱氨酸甲基化生成蛋氨酸反应的甲基供体。MTHFR基因的多态性(C677T,A1298C)会造成酶的活性降低,从而影响疾病的发病率。已有研究表明MTHFR的基因多态性与肺癌的发病率显著相关,文章对MTHFR基因多态性与肺癌的关系作一综述。

Folate metabolism is thought to play an important role in lung cancer through its involvement in both DNA methylation and nucleotide synthesis. Methylenetetrahydrofolate reductase （MTHFR） is an important folate metabolizing enzyme that catalyzes methylenete- trahydrofolate into 5-methyltetrahydrofolate, which is the methyl donor for remethylation of homocysteine to methionine. Certain common polymorphisms within the MTHFR gene （C677T, A1298C） result in reduced enzymatic activity and have been associated with reduced risk for a variety of disease. According to former experiments, MTHFR polymorphisms are associated with lung cancer which is also affected with lots of other elements. This article summarized several conclusions of different experiments involving MTHFR polymorphisms and lung cancer.