尼索地平治疗原发性高血压的疗效

The Clinical Efficacy of Nisoldipine in Essential Hypertension

目的为验证新型钙离子拮抗剂尼索地平的临床降压疗效。方法采用随机双盲对照法，临床口服尼索地平（10～20mg，Bid）与尼群地平（10～20mg，Bid）对75例轻中型原发性高血压患者进行对比研究。结果尼索地平具有良好的降压作用，总有效率91．4％，显效率60％。结论尼索地平优于尼群地平，无明显心肌的负性收缩作用和其它不良反应，是一种安全，良好，服用方便的抗高血压药物。

Objective To prove the clinical efficacy of Nisoldipine (a new calcium channel antagonist). Methods We used the randomized double blind and parallel control design to study the effect of Nisoldipine (10～20mg, Bid) in 75 patients with mild to moderate essential hypertension compared with that of Nitrendipine (10～20mg, Bid). Results The total effective rate of Nisodipine was 91.4% and the remarked efficacy rate was 60%, better than those of Nitrendipine and it also has fewer side effect. Conclusion It suggested that Nisoldipine is an effective, safe and well tolerated antihypertensive agent.