摘要
目的探讨血糖水平对局灶性脑缺血后脑水肿的影响。方法Wistar大鼠被分为正常血糖组（n=8）和高血糖组（n=8），采用凝闭左侧大脑中动脉造成局灶性脑缺血模型。应用比重梯度法测定两组动物在大脑中动脉凝闭后6h缺血脑组织比重的变化。结果高血糖组和正常血糖组大鼠在大脑中动脉闭塞后6h，缺血侧皮质和基底节区脑组织比重较对照侧明显降低（P＜0．01），且高血糖组大鼠缺血侧皮质和基底节区脑组织比重较正常血糖组降低明显（P＜0．01和P＜0．05）。结论高血糖可加重局灶性脑缺血后脑水肿的程度，从而产生更严重的神经功能障碍。
Objective The sutdy was to explore whether blood glucose levels effect on brain edema after focal cerebral ischemia. Methods We determined changes of brain water content 6h after middle cerebral artery occlusion(MCAO) in normoglycemic and hyperglycemic rats with density gradient columns of specific gravity. Results We found that brain tissue (cortex and hasal ganglia) specific gravity of ischemic side declined significantly 6h after MCAO in the two groups (P＜0.01). In addition, we found that the reduction of brain tissue specific gravity in the hyperglycemic group was more significantly than that of the normoglycemic group (cortex P<0.01 and hasal ganglia P<0.05 respectively). Conclusion The results suggest that hyperglycemia can exacerbate brain edema after MCAO.
出处
《上海第二医科大学学报》
CSCD
1999年第2期161-163,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
高血糖
脑缺血
脑水肿
脑比重
hyperglycemia
cerebral ischemia
brain edema
brain specific
gravity
