胃癌组织中MTA1蛋白及微血管密度检测

Expression of MTA1 protein and MVD in gastric carcinoma tissue

目的:研究正常胃黏膜及胃癌组织中MTA1蛋白和微血管密度(MVD)的表达情况及相互关系。方法:采用免疫组织化学法分别检测12例正常胃黏膜及63例胃癌组织中MTA1蛋白及MVD的表达情况。结果:正常胃黏膜及胃癌组织中MTA1蛋白阳性表达率分别为33.3%(4/12)和80.9%(51/63),差异有统计学意义(χ2=9.380,P=0.002);MVD值分别为(18.25±8.35)和(45.38±8.69),差异有统计学意义(t=9.974,P<0.001);胃癌组织中MTA1蛋白的表达与胃癌的浸润深度、分化程度及淋巴结转移有关(χ2分别为8.129、12.770和6.254,P均<0.05);MTA1蛋白表达者MVD值(47.49±7.69)高于MTA1蛋白未表达者(36.77±5.71)(t=5.265,P<0.001)。结论:MTA1蛋白过表达可能是胃癌浸润、转移和微血管生成的一个促进因素。

Aim：To explore the expression of MTA1 and microvessel density（MVD） and their relationships in gastric carcinoma tissue.Methods：The expressions of MTA1 and MVD were detected by immunohistochemistry in 12 cases of normal gastric mucosa tissues and 63 cases of gastric carcinoma tissues.Results：In normal gastric mucosa and gastric carcinoma,the positive expression rate of MTA1 was 33.3%（4/12） and 80.9%（51/63） respectively,and there was significance difference （χ2=9.380,P=0.002）.The MVD index was （18.25±8.35） and （45.38±8.69）,and there was significance difference（t=9.974,P0.001）.The positive expression rate of MTA1 was significantly related with the depth of tumor invasion,differentiation degree and lymph node metastasis （χ2=8.129,12.770,and 6.254,P0.05）. The mean of MVD in the carcinoma tissue with the positive expression of MTA1 protein （47.49±7.69） was higher than in the tissue with the negative expression of MTA1 protein （36.77±5.71） （t=5.265,P0.001）.Conclusion：MTA1 protein may play an important role during gastric carcinoma＇s invasion,metastasis and microvessel＇s production.