贲门癌切除术后生存10年以上病例分析

Analysis of patients survived over ten years after resection of gastric cardia carcinoma

目的探讨影响贲门癌切除术后长期生存的因素。方法对５８４例贲门癌切除术后生存１０年以上的病例进行回顾性分析。结果本组１０年生存率为１７．１％。肿瘤的病理分期、分化程度、大体类型、瘤体大小对１０年生存率的影响均有显著性（Ｐ＜０．０５）。有无淋巴结转移对１０年生存率的影响有非常显著性（Ｐ＜０．０１）。伴有切端癌残留、癌栓形成、肿瘤浸润浆膜、手术切除性质，以及性别、年龄、病程等对１０年生存率影响无显著性（Ｐ＞０．０５）。结论贲门癌的早期发现、早期诊断、早期切除治疗仍是提高其１０年生存率的关键。切端癌残留、癌栓形成。

Objective To investigate factors affecting long term survival in patients with resected gastric cardia cancer. Methods Survival was analyzed retrospectively in 584 patients with gastric cardia carcinoma who received tumor resection from 1964 through 1982. Results The 10 year survival rate was 17.1%. The major factors influencing survival were clinical staging, degree of differentiation, gross tumor type and size ( P <0.05) and status of lymph node metastasis ( P <0.01). Residual tumor at resection edge and tumor thrombi did not significantly affect survival, nor did sex, age, and course of the disease. Conclusion Early detection, early diagnosis and early surgical resection are the key to improve 10 year survival of patients with resected cancer of the gastric cardia. Why residual tumor left at the resection edge and the presence of tumor thrombi do not influence survival needs to be further studied.