微量^(14)C-尿素呼吸试验诊断幽门螺杆菌感染的评价

Evaluation of trace of ^(14)C-Urea breath test in diagnosing helicobacter pylon infection.

目的:研究(１４)Ｃ－尿素呼吸试验（ＵＢＴ）诊断幽门螺杆菌（ＨＰ）感染的应用价值。方法对１１９例有上消化道症状而就医的患者同时做(１４)Ｃ－尿素呼吸试验、快速尿素酶试验（ＲＵＴ）、组织切片Ｗａｒｔｈｉｎ－Ｓｔａｒｒｙ银染色。将上述三种方法的敏感度、特异度、准确度加以比较。结果(１４)Ｃ－ＵＢＴ的特异度高于ＲＵＴ（Ｐ＜０．０５），三者的准确度比较无显著性差异（Ｐ＞０．０５）。结论(１４)Ｃ－ＵＢＴ具有简便、可靠、安全、无交叉感染及无创伤性等优点。

Objective To study the application value of 14C-urea breath test (14C-UBT) in diagnosing Helicobacter pylon (HP) infection. Methods 119 patients who upper gastrointestinalsymptoms were investigated with 14C-UBT, rapid urease test (RUT), and antral biopsy specimensfor Warthin-Starry stain at the same time. We compared the sensitivity, specificity, and accuracyof three methods. Results Specificity of 14C-UBT was higher than that of RUT (P<0. 05). Accuracy of these three methods are not statistically different (P>0. 05). Conclusion Our findings indicate that the 14C-UBT is a simple, safe, and non-invasive test.