支气管肺泡灌洗液T细胞亚群测定在间质性肺炎鉴别诊断中的意义

Effect of BALF cytology in distinguishing ILD

目的了解支气管肺泡灌洗液（ＢＡＬＦ）Ｔ细胞亚群在鉴别诊断普通型间质性肺炎（ＵＩＰ）和闭塞性细支气管炎伴机化性肺炎（ＢＯＯＰ）中的意义。方法分别对经病理学证实的、不吸烟的８例ＵＩＰ和８例ＢＯＯＰ的ＢＡＬＦ中细胞分类计数和Ｔ淋巴细胞亚群进行了检查。结果两组相比，ＢＯＯＰ组的淋巴细胞比率、ＣＤ＋８细胞比率均明显升高，而ＣＤ＋４／ＣＤ＋８比率明显降低（皆Ｐ＜００１）；ＵＩＰ组的中性粒细胞明显升高（Ｐ＜００５）。结论ＢＡＬＦ中细胞分类计数和Ｔ淋巴细胞亚群测定。

Objective To know the characteristic features in BALF samples of patients with BOOP and UIP. Methods Differential cell count and T-cell subsets of the BALF obtained from 8 patients with UIP and 8 patients with BOOP,both histologically verified,were examined. Results In BOOP patients the ratio of lymphocytes and the CD + 8 cell in BALF were significantly higher and CD + 4/CD + 8 ratio was significantly lower than those of the UIP patients (P<0 01).In UIP patients the ratio of neutrophils in BALF was significantly higher than that of BOOP patients (P<0 05) Conclusions Cytological examination of BALF is effective in differentiating BOOP from UIP and it can provide useful information about both different pathogenetic processes of the two entities.