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转铁蛋白受体单克隆抗体偶联物动脉灌注法治疗晚期肺癌

Intra arterial Chemotherapy of Late Stage Lung Cancer,Using Conjugates of Monoclonal Antitransferrin Receptor Antibody and Drugs Attatched Chemotherapy
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摘要 为了观察转铁蛋白受体单抗偶联物对晚期肺癌的疗效,采用转铁蛋白受体单克隆抗体与表阿霉素、顺铂等化学药物制成偶联物,对38例中晚期肺癌进行选择性支气管动脉插管灌注,结果:CR12例,占31.6%,PR17例,占44.7%,NC7例,占18.4%,PD2例,占5.3%,总有效率(CR+PR)为76.3%。通过病例观察,支气管动脉插管导向灌注疗法比单纯化疗药物动脉灌注的疗效为优,且副作用小。 To observe the therapeutic effect of conjugates of monocolonal antitransferrin receptor antibody and drugs chemotherapy in the late stage lung cancer,we treated 38 cases of medium and late stage lung cancer through selective bronchial artery intra arterial chemotherapy,using conjugates of monocolonal antitransferrin receptor antibody and drugs(such as pharmorubincin and cisplatin,etc.).The results showed:The rate of significant tumor shrinkage(CR) was 31.6%(12 cases),and partial(PR) 44.7%(17 cases),and no change(NC) 18.4%(7 cases).The rate of tumor growth(PD) was 5.3%(2 cases).The total effective rate(CR+PR) was 76.3%.It suggested that compared to intra arterial chemotherapy(simply using chemotherapy drugs),this conjugated method would give better therapeutic effect and slighter side effect.It may be a new and effective way for the palliative treatment of medium and late stage lung cancer.
机构地区 上海同仁医院
出处 《实用癌症杂志》 1999年第1期44-45,共2页 The Practical Journal of Cancer
关键词 晚期 肺癌 支气管动脉 单克隆抗体 灌注疗法 TFR Late stage lung cancer Bronchial artery Monoclonal antitransferrin receptor antibody
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参考文献6

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