不同剂量的氟比洛芬酯注射液治疗顽固性肾绞痛的疗效观察

Observation of the curative effect of different dosage of flurbiprofen applied in refractory renal colic cases

目的 观察不同剂量的氟比洛芬酯注射液治疗顽固性肾绞痛的疗效和不良反应.方法 对200例顽固性肾绞痛患者采用抽签法随机分为A、B两组,每组各100例,A组给予氟比洛芬酯注射液100 mg静脉注射,B组给予氟比洛芬酯注射液50 mg静脉注射,对两组的镇痛效果及不良反应进行观察比较.结果 A组总有效率99%（991100）,B组9l%（91/100）,两组总有效率比较差异有统计学意义（P〈0.05）.A组药物起效时间（8.3 4±5.7）min,明显短于B组的（13.2±9.1）min（P〈O.05）.但A组疗效持续时间[（19.3±3.2）h]与B组[（14.5±5.1）h]比较差异无统计学意义（P〉0.05 o两组不良反应均较轻微.结论 100 mg和50 nag的氟比洛芬酯注射液治疗顽固性肾绞痛均有效,但100mg氟比洛芬酯注射液起效更迅速,镇痛效果更确切,不良反应未增加.

Objective To observe the curative effect and side effect ofdifferent dosage of flurbiprofen applied in refractory renal colic cases.Methods Two hundred refractory renal cohc cases were randomly divided into group A and group B,each group was 100 cases.Group A were apphed 100 mg flurbiprofen injection,group B were applied 50 mg flurbiprofen injection.Observed the time of the colic pain reheved,the curative effect and side effect Results The total effective rate of group A and group Bwere 99%（99/100）and 91%（911100）respectively,there was significant difference between two groups（P〈0.05）.In the time to relieve of group A and group B were（8.3±5.7）min and（13.2±9.1）min respectively,there Was significant difference between two groups（P〈0.05）.Analgesia continuous time of group A and group B were（19.3 ±3.2）h and（14.5 4±5.1）h respectively,there was no significant difference between two groups（P〉0.05）.And side effect was no significant difference between two groups.Conclusion The curative effect of 100mg flurbiprofen injection applied to the refractory renal colic cases is very outstanding,the time to relieve is very shod but side effect dose not increase.