沐舒坦治疗慢性阻塞性肺疾病缓解期疗效观察

Effects of Mucosolvin on stable chronic obstructive pulmonary disease

目的:观察沐舒坦对慢性阻塞性肺疾病(COPD)缓解期患者的治疗效果。方法:60例COPD缓解期入选病例,随机分为观察组和对照组,观察组在对照组治疗的基础上加用沐舒坦口服,随访1年。于治疗前后临床问卷调查及体征检查评分,观察治疗期间病情急性加重次数。结果:治疗1年后观察组临床症状评分显著改善(P<0.05),而对照组无明显改善(P>0.05),且治疗组治疗期间急性加重次数较对照组明显减少(P<0.05)。结论:沐舒坦可改善COPD缓解期患者的临床症状并减少急性加重次数。

Objective：To observe the curative effects of Mucosolvin on patients with stable chronic obstructive pulmonary disease（COPD）.Methods：60 patients with stable COPD were divided into observation group and control group randomly.Patients in control group received conventional therapy and patients in observation group received both oral Mucosolvin and conventional therapy.Scores on the clinical symptom questionnaire,scores on physical sign checks and the frequencies of acute exacerbation were evaluated before and after one-year treatment.Results：There were significant difference of observation group after one-year treatment on scores on clinical symptom（P〈0.05）,while no significant difference of control group was found（P〉0.05）.Compared with control group,the frequencies of acute exacerbation of observation group were reduced more significantly（P〈0.05）.Conclusion：Mucosolvin can improve the clinical symptom and reduce the frequencies of acute exacerbation of patients with stable COPD.