血管内皮生长因子基因C(—634)G多态性及血浆血管内皮生长因子水平与糖尿病视网膜病变的相关性研究

Relationship of VEGF gene C(-634)G polymorphism and plasma level of VEGF with diabetic retinopathy

目的探讨血管内皮生长因子(VEGF)基因C(-634)G多态性及血浆中VEGF水平与糖尿病视网膜病变(DR)的关系。方法在昆明地区汉族人中检测96名正常对照者(NC组)和285例T2DM患者的VEGF基因C(-634)G多态性及血浆中VEGF水平。结果 DR组CC基因型和C等位基因频率显著高于非DR(NDR)组(P均<0.05),DR组中CC基因型者血浆VEGF水平高于CG及GG基因型者和NC组(P<0.05或P<0.01)。结论 VEGF基因C(-634)G多态性是昆明地区汉族T2DM患者发生DR的危险因素。

Objective To investigate the relationship of vascular endothelial growth factor（VEGF） gene C（- 634）G polymorphism and plasma level of VEGF with diabetic retinopathy in Kunming Han Chinese. Methods VEGF gene C（-634）G polymorphisms and plasma level of VEGF were analyzed in 285 patients with type 2 diabetes and 96 healthy control subjects. Results The frequencies of CC genotype and C allele were significantly higher in diabetic retinopathy（DR） group than in non-proliferative diabetic retinopathy（NDR）group（P〈0.05）. Individuals with CC genotype had higher plasma VEGF level than those with CG and GG groups. Conclusions The C（-634）G polymorphism of VEGF gene is related to DR in Han Chinese with type 2 diabetes in Kunming.