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脂蛋白相关磷脂酶A2与血管性认知功能障碍的相关性研究 被引量：2

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摘要 目的探讨血管性认知功能障碍(vascular cognitive impairment,VCI)的两个亚型:非痴呆型血管性认知障碍(Vascular Cognitive Impairment No Dementia,VCIND)、血管性痴呆(Vascular de-mentia,VaD)患者血清中脂蛋白相关磷脂酶A2(lipoprotein-associated-phospholipase A2,LP-PLA2)含量变化及临床意义。方法 VCIND患者47例、VaD患者29例,对照组31例,测定各组血清中Lp-PLA2水平。结果 VaD组血清Lp-PLA2含量(60.23±1.37)μg/L较VCIND组血清Lp-PLA2含量(20.26±1.28)μg/L高(P<0.05);VCIND组血清Lp-PLA2含量(20.26±1.28)μg/L较对照组血清Lp-PLA2含量(10.18±0.19)μg/L高(P<0.05)。结论血清Lp-PLA2水平能客观地反映VCI的认知功能损害程度,血清Lp-PLA2水平与VCI的认知功能障碍具有相关性,Lp-PLA2可能是血管性认知功能障碍的独立危险因素,对VCI有一定的临床诊断价值。
作者 白洁 苏志强
机构地区 哈尔滨医科大学第一临床医学院神经内二科
出处 《齐齐哈尔医学院学报》 2010年第8期1192-1194,共3页 Journal of Qiqihar Medical University
关键词 血管性认知功能障碍 脂蛋白相关磷脂酶A2 非痴呆型血管性认知障碍 血管性痴呆
分类号 R749.13 [医药卫生—神经病学与精神病学]
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参考文献10

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共引文献363

同被引文献28

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引证文献2

二级引证文献13

齐齐哈尔医学院学报
2010年 第8期

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