大肠癌组织中VEGF及其受体KDR的表达与预后的关系

Expression of vascular endothelial growth factor and its kinase insert domain containing receptor in colorectal cancer tissue and its relation with the prognosis of colorectal carcinoma

目的探讨VEGF及其受体KDR在大肠癌组织中的表达与预后的关系。方法应用免疫组织化学法检测60例大肠癌标本中VEGF及其受体KDR的表达情况;随访统计患者5年生存率。结果 VEGF及其受体KDR在大肠癌组织中的表达阳性率分别为61.7%及68.3%;二者在大肠癌组织中的表达与肿瘤侵袭深度、是否淋巴结转移及Dukes分期密切相关(P<0.05)。VEGF及KDR阳性5年生存率分别为43.2%及51.2%;阴性5年生存率分别为87.0%及78.9%;差异有统计学意义(P<0.05)。结论大肠癌组织中VEGF及其受体KDR的阳性表达提示患者预后差,可作为评价预后的指标。

Objective To study the expression of vascular endothelial growth factor （VEGF） and its kinase insert domain containing receptor （KDR） in colorectal cancer tissue and its relation with the prognosis of colorectal carcinoma. Methods Expression of VEGF and its KDR in colorectal carcinoma tissue from 60 cases was examined with immunohistochemical staining. The patients were followed up and their 5-year survival rate was observed. Results The positive VEGF and its KDR expression rate in colorectal cancer tissue was 61.7% and 68.3%, respectively, which was closely related with the deepness of invasion, lymph node metastasis and Dukes stage （P〈0.05）. The 5-year survival rate for patients with positive VEGF and its KDR expression was 43.2% and 51.2%, respectively, while the 5-year survival rate for those with negative VEGF and its KDR expression was 87.0% and 78.9%（P〈0.05）. Conclusion Positive VEGF and its KDR expression in colorectal cancer tissue can be used as an indicator for the prognosis of patients with colorectal carcinoma.