TIM-3与器官移植免疫耐受的研究现状
TIM-3 and organ transplantation immune tolerance
摘要
Th1介导的迟发型超敏反应不仅引起急性排斥反应,而且其间断活化产生的细胞因子和炎性介质直接导致慢性移植物失功。TIM-3-Galectin-9信号通路可以选择性抑制Th1型细胞反应,有望为器官移植免疫耐受的诱导提供新途径。
出处
《军医进修学院学报》
CAS
2010年第7期732-733,共2页
Academic Journal of Pla Postgraduate Medical School
基金
国家科技支撑计划项目(2008BA160B04)
全军"十一.五"计划科研项目资助课题(06G115)~~
参考文献12
-
1Lechler RI, Sykes M, Thomson AW, et al. Organ transplantation- how much of the promise has been realized [ J ] . Nat Med, 2005, 11 (6) : 605-613.
-
2Monney L, Sabatos CA, Gagha JL, et al. Thl-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease [ J ] . Nature, 2002, 415 : 536-541.
-
3Meyers JH, Sabatos CA, Chakravarti S, et al. The TIM gene family regulates autoimmune and allergic diseases [ J ] . Trends Mol Med, 2005, 11 (18): 362-369.
-
4Nakae S, Iwakura Y, Suto H, et al. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17 [J] .J leukoc Biol, 2007, 81 : 1258-1268.
-
5Wada J, Kanwar YS. Identification and characterization of galectin-9, a novel beta-galac-toside-binding mammalianlectin [ J ]. J biol Chem, 1997, 272 : 6078-6086.
-
6Zhu C, Anderson AC, Schubart A, et al. The Tim-3 ligand galectin-9 negatively regulates T helper typel immunity [ J ] . Nat Immunol, 2005, 6 : 1245-1252.
-
7Seki M, Oomizu S, Sakata K, et al. Galectin-9 suppresses the generation of Th 17, promotes the induction of regulatory T cells, and regulates experimental autoimmune-arthritis [ J ] . Clin Immunol, 2008, 127 : 78-88.
-
8Sanchez-Fueyo A, Tian J, Picatella D, et al. Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immulogical tolerance [ J ]. Nat Immunol, 2003, 4 ( 11 ) : 1093- 1101.
-
9Sabatos CA, Chakravarti S, Cha E, et al. Interactionof Tim-3 and Tim-3 ligand regulates T helper type1 responses and induction of peripheral tolerance [J].Nat Immunol, 2003, 4 (11): 1102- 1110.
-
10Renesto PG, Ponciano VC, Cenedeze MA, et al. High expression of Tim-3 mRNA in urinary cells from kidney transplant recipient with acute rejection [ J ]. Am J Transplant, 2007, 7 ( 6 ) : 1661-1665.
-
1王绕绕,宋红丽.自噬在器官移植免疫耐受研究中的进展[J].实用器官移植电子杂志,2016,4(1):57-60. 被引量：7
-
2叶晟.器官移植免疫耐受研究概况[J].免疫学杂志,2001,17(z1):87-90. 被引量：2
-
3唐韵成,曾强,窦剑.调节性T细胞在器官移植免疫耐受中的研究进展[J].器官移植,2014,5(1):54-56. 被引量：2
-
4刘静,管德林,韩志友,和布郎,韩修武,李晓北,田溪泉.他克莫司治疗移植肾慢性排斥的初步临床观察[J].肾脏病与透析肾移植杂志,2002,11(6):524-527. 被引量：2
-
5刘忠国,温端改.器官移植诱导免疫耐受的研究进展[J].国外医学（泌尿系统分册）,2005,25(6):743-748.
-
6张鑫,王立明.肾移植长期存活相关生物标志物的研究进展[J].第二军医大学学报,2012,33(2):212-215.
-
7高红强,黄江波.青藤碱在器官移植免疫耐受方面的研究进展[J].中国实用医药,2014,9(8):259-261. 被引量：7
-
8周丽侠,赵书元.组织损伤的细胞反应:水肿[J].国外医学（护理学分册）,2004,23(7):317-319.
-
9贾克东.肝硬化脾功能亢进的几个问题[J].江苏卫生保健（今日保健）,2016(2):9-9.
-
10刘小村,刘小群,张百萌.同种异体器官移植免疫耐受的机理研究进展[J].中国误诊学杂志,2004,4(7):1013-1016. 被引量：3
