磺胺类药物半抗原的合成及结构表征

Synthesis and Structure Elucidation of Sulfonamide Haptens

本试验合成了4个模拟磺胺类药物母核结构的半抗原，使用1HNMR，FABMS和IR对半抗原结构进行了鉴定。产物结构中，4种间隔臂均位于对氨基本磺酞肤的N1端（-SO4NH-，突出了磺腔类药物的共同结构部分，为预期的半抗原。

Four sulfonamide haptens were synthesized and identified by 1HNMR, FABMSand IR. ln these structures, the four spacer arms were linked to N1 section of 4-aminoben-zensulfonamide, and the feature common to sulfonamides was exposed.