高钠所致肉用雏鸡肺动脉高压模型的心电图学研究

ELECTROCARDIOGRAPHIC EVALUATION ON THE MODEL OF PULMONARY HYPERTENSION OF BROILER CHICKENS INDUCED BY HIGH CONCENTRATION OF SODIUM ION FROM SODIUM CHLORIDE IN DRINKING WATER

本试验用心电描记法对３组共２８５羽健康ＡＡ肉鸡从８日龄开始分别饮用含氯化钠００％、０１５％、０３０％的饮水所致肉用雏鸡肺动脉高压综合征（ＰｕｌｍｏｎａｒｙＨｙｐｅｒｔｅｎｓｉｏｎＳｙｎｄｒｏｍｅ，ＰＨＳ）进行了研究，结果表明：（１）实验组的右心室（ＲｉｇｈｔＶｅｎｔｒｉｃｌｅ，ＲＶ）和全心室（ＴｏｔａｌＶｅｎｔｒｉｃｌｅ，ＴＶ）的重量比（ＲＶ／ＴＶ）较对照组显著增高。（２）回归分析表明Ⅱ、ａＶＦ导联Ｓ波波幅的变化与ＲＶ／ＴＶ和（ＲＶ／ＴＶ）／ＢＷ（Ｂｏｄｙｗｅｉｇｈｔ）的变化呈强负相关（Ｒ＝－０７９８～－０８１２）；平均组合向量（ＭｅａｎＲｅｓｕｌｔａｎｔＶｅｃｔｏｒ，ＭＲＶ）的变化与ＲＶ／ＴＶ和（ＲＶ／ＴＶ）／ＢＷ呈强正相关（Ｒ＝＋０７２３～＋０７２８）。（３）对照组、实验Ⅰ组、实验Ⅱ组分别有００％，６２５％，２８７５％鸡发展成临床型腹水。因此心电图上的这些特征性变化可作为ＰＨＳ早期阶段的一个准确、可靠的指标。另外，跟踪心电图显示最初的Ｒｓ和ｒＳ波型在ＰＨＳ的易感性上差异显著，Ｒｓ波型可作为一项很有希望的抗ＰＨＳ的育种指标。

Two hundred and eighty five broiler chickens were divided into three groups evenly and treated with 0 0%,0 15% and 0 30% sodium chloride in their drinking water at 8 days of age.Electrocardiography was used as a nonivasive method for detecting broilerscardiac hypertrophy associated with Pulmonary Hypertension Syndrome(PHS,Ascites).It was indicated:①The right ventricular to total Ventricular weight ratio (RV:TV) was higher in the treatment groups than in the control groups.②When data from all treatment groups were combined by regression analysis,higher absoulute and BW normalized RV:TV ratios were inversely correlated(r=-0 798 to -0 812) with increasingly negative S wave amplitudes in Lead Ⅱ and aV F.Higher absoulute and BW normolized RV:TV ratios were directly correlated(r=+0 723 to+0 728) with increasing MRV amplitlldes.③The Control,Treatment Ⅰ and Treatment Ⅱ groups had 0 0%,6 25% and 28 75% incidence of clinical ascites respectively.Above all,these ECG characteristics constitute accurate,noninvasive predictive criteria suitable for detecting cardiaic changes occurring early during the onset of primary pulmonary hypertension.Secondly,the results of ECG studies indicate that the PHS susceptibility of population of broilers in the present study(Rs and rS.rS +)based on VCG analysis of the MEA is tremendous difference.The RS population maybe regarded as a criteria in resisting PHS.