隆突性皮纤维肉瘤37例临床分析

A Clinical Analysis of 37 Cases Dermatofibroma Protuberans

自1977年7月至1989年10月共收治隆突性皮纤维肉瘤病人37例,根据治疗方法分为单纯手术组(S)和手术+放疗组(S+R)。两组的3、5、7、10、15年生存率各为:S组864%、864%、636%、545%、45%及S+R组100%、933%、80%、60%、333%,两组生存率比较,仅15年生存率有意义(P<005)。不论是首次治疗还是复发后再治疗,S+R组的5年无瘤生存率均优于S组(P<001)。肿瘤最大径<7cm预后较好。本病治疗主张作扩大肿块切除,术后提倡放疗。

From Jul 1977 to Oct 1989 37 cases of dermatofibroma protuberans (DFP) were treated either with surgery alone (S) or with surgery plus radiotherapy (S+R) The 3,5,7,10,15-years survival rates in two groups were; S group 86 4%,86 4%,63 6%,54 5%,4 5% and S+R group 100%,93 3%,80%,60%,33 3% Only the 15-year survival rate was significant for the S+R group as comp ared to the S group. The 5-year disease free survival rate was significantly better for the S+R group as compared to the S group (P<0 01) either the first therapy or the secondary therapy after recurrence The prognosis was better when the maximum tumor size was smaller than 7 cm Radiotherapy is recommended after expansive oncological resection in the light of the treatment of DFP