血清CEA测定及免疫显像诊断卵巢癌的研究

A STUDY OF PLASMA CEA MEASURED AND RADIOIMMUNOIMAGING OF OVARIAN NEOPLASMA WITHI-131 LABELLED CEA MONOCLONAL ANTIBODY

对19例卵巢肿瘤患者进行了术前血清CEA测定和^(131)I-CEA单克隆抗体免疫显像,使用γ-闪烁显像辅以微机图像处理技术获得较好效果。19例均经手术病理证实。12例卵巢癌术后复发病人7例血清CEA>0.15mg/L,11例免疫显像阳性,1例假阴性。7例卵巢良性肿瘤1例血清CEA>0.15mg/L,免疫显像均为阴性。免疫显像在发现转移灶的同时亦可直接显示病灶的位置,形态,大小与数量。

12 cases of recurrent ovarian cancers and 7 cases of benign ovar-ian tumor have been detected with I-131 labelled CEA McAb and computedassisted dual radionuclide subtraction technique.11 of 12 recurrent ovarian cancers could be localized with radioactivity McAb to CEA.7 benignovarian tumors were all negative imaging.The lesions(primary or second-ary)are clearly visualized and proved by surgical and pathohistological find- ings.32 of 34 metastatic lesion are localized.Plasma CEA were measured inall patients before radioimmunoimaging.From the results,radioimmunoimag-ing seems to be a sensitive and specific procedure for the diagnosis ofovarian neoplasma.It is also valuable for clinical staging,follow-up andmaking decision or treatment,assessing the prognosis of recurrent ovariancancer as well.