摘要
将BALB/c小鼠分为猪胸腺素(ST)组、猪胸腺素+维生素E(ST+VE)组、维生素E(VE)组和生理盐水(NS)组,研究发现ST、ST+VE两组脾细胞LCLPFC与血浆cGMP,胸腺重量及生存期均显著高于NS组,肿瘤发生率低于NS组。临床观察117例中老年人,ST组的Et,Ea,LCT,OT值与一般生理机能均显著提高,CIC,AA与感染性疾病减少,VE组除Et,LCT提高和CIC,AA减少外,余无明显改变。停ST12个月时,LCT值下降明显,消化系感染疾病增多,提示停药1年时应适当补充ST。
The result of animal experiment with BALB/c mice(10 months
age)showed that the spleen LCT and PFC,plasma cGMP,thymus weight and
survival time of the groups treated with swine thymosin(ST)only and ST
combined with VE were significantly higher and the rate of tumor incidence
were lower than that of saline control group,and there was no difference
between YE group and saline control group.Clinical study showed that the
Et,Ea,LCT OT value and general physical function of fifty nine middleaged
and aged people treated with ST increased significantly,and the CIC,AA
and the rate of infectious incidence decreased considerablly,but the parame-
ters of the group treated with VE had no valuable change except the increase
of LCT and CIC and the decrease of AA,When the use of ST had been
stopped for 12 months,the value of LCT decreased considerablly and the rate
of the infectious incidence of alimentary system increased.The phenomenon
suggests that appropriate amount ST should be supplied again after the use
of ST stopped for 1 year.
出处
《山东医科大学学报》
1990年第3期69-73,共5页
Acta Academiae Medicinae Shandong
关键词
胸腺素
免疫活性
猪
老年人
小鼠
Thymosin
Swine
Immunocompetence
Aged
Mice,inbred BALB/c
