矽肺与抗氧化剂、抗氧化酶关系的探讨

Study on the correlation of silicosis with antioxidant and antioxidasec8

目的：探讨矽肺与抗氧化剂、抗氧化酶的关系。方法：检测了７３例矽肺患者和６０例健康对照者的血浆维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）、过氧化氢酶（Ｅ－ＣＡＴ）、谷胱甘肽过氧化物酶（Ｅ－ＧＳＨ－Ｐｘ）活性。结果：与对照组比较，患者组的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ、Ｅ－ＳＯＤ、Ｅ－ＣＡＴ、Ｅ－ＧＳＨ－Ｐｘ平均值均显著降低（Ｐ＜０．００１）；各检测值与患者病程、病情、肺功能状态均有相关；逐步回归表明患者病程、病情、肺功能状态与Ｐ－ＶＥ、Ｅ－ＳＯＤ值相关最为密切。结论：矽肺患者体内氧化抗氧化平衡严重失调，氧自由基反应病理性加剧。

Plasma vitamin C(P VC),vitamin E(P VE) and β carotene(P β CAR) contents and the activities of superoxide dismutase(E SOD),catalase(E CAT) and glutathione peroxidase (E GSH Px) in erythrocyte in 73 silicosis patients and 60 healthy control subjects were measured.The average levels of P VC,P VE,P β CAR, E SOD,E CAT andE GSH Px of patients were significantly lower than those of the controls ( P <0 001).All indexes were correlated to the course,condition and pulmonary function of silicosis patients.The results analyzed by stepwise regression showed that the correlation between course,condition and pulmonary function of patients and P VE and E SOD was close.The balance between oxidation and the antioxidation in silicosis patients may be disturbed,and oxygen free radical reaction may be pathologically exacerbated.