摘要
目的探讨血清游离态PSA(FPSA)和总PSA(TPSA)及游离态/总(F/T)PSA比值作为前列腺疾病诊断指标的价值。方法测定56例未经治疗的BPH病人和39例前列腺癌病人血清FPSA和TPSA,并计算F/T比值。结果TPSA及F/T可有效区分BPH和前列腺癌(P<0.005),尤其在诊断灰区(TPSA为4.0~10.0μg/L)中效果更明显。以TPSA≤10.0μg/L,F/T≥0.16为界值时,前列腺癌筛选的临床概率敏感度为94.7%。结论FPSA和F/T比值的引入,使血清PSA测定更为精细,保持了实验的高敏感度。
Objective To evaluate serum free PSA(F PSA), total PSA(T PSA)and free/total (F/T)ratio as an indicator for the differential diagnosis between BPH and PC. Methods Serum samples were obtained from 56 men with untreated BPH and 39 men with untreated prostate cancer. Free PSA and F/T PSA levels of all samples were determined using free PSA and Equi Molar PSA diagnostic kits. Results When all subjects were detected both total PSA and the free to total PSA ratio were significantly different between patients with prostate cancer and patients with BPH ( P <0.005 ),in especialy,in men with total PSA values between 4. 0~10.0 μg/L (the diagnostic gray zone),when F/T≥0.16 was taken as the cutoff value, the sensitivity was as high as 94.7%. Conclusions With the introduction of free PSA and F/T ratio,the early detection of PC by the assessment of PSA has been made more sensitive and reliable especially when the PSA is within the diagnostic gray zone.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1999年第4期243-245,共3页
Chinese Journal of Urology