摘要
用Ｆｒｅｕｎｄ完全佐剂诱发大鼠产生佐剂性关节炎（ＡＡ），以继发性反应的左后足肿胀度、前肢、身和尾部病变的发生率，胸腺、脾脏指数以及局部组织病理检查为指标，观察卡巴匹林钙对ＡＡ的治疗作用。结果表明卡巴匹林钙大、中剂量（７６３，３８２ｍｇ／ｋｇ）在给药后８天可显著降低ＡＡ大鼠非致炎侧的足肿胀度，全身症状也明显减轻，非致炎侧踝关节的水肿和炎细胞浸润明显减轻。
Adjuvant arthritis(AA) in rats was induced by Freunds complete adjuvant. The secondary reactions were observed including swelling degree in the left hind paw, changes in the fore leges, ears and tail, and thymus and spleen indexes. Carbasalatum calcium at the dosage of 763,382mg/kg produced a significant suppression in uninjected hind paw edema of AA rats at 8th day after the administration of drug. The polyarthritis symptoms of the whole body in AA rats treated with carbasalatum calcium were markedly relieved. The reduction of edema and the infiltration of inflammatory cells in the uninjected ankle of AA rats were found by means of pathohistological examination. These results suggest that carbasalatum calcium has therapeutic effects on AA in rats.
出处
《山东医科大学学报》
1999年第1期77-78,81,共3页
Acta Academiae Medicinae Shandong
