摘要
应用牛脑微血管内皮细胞（ＢＣＭＥＣ）培养技术，研究氧自由基过氧化氢（ＨＰ）对ＢＣＭＥＣ损伤的作用。３０％ＨＰ（３μｍｏｌ／ｍｌ）与ＢＣＭＥＣ共同孵育３０ｍｉｎ，可明显损伤ＢＣＭＥＣ；甘糖酯（０．４、０．８、１．６ｍｇ／ｍｌ）可显著保护ＨＰ引起的ＢＣＭＥＣ损伤，乳酸脱氢酶（ＬＤＨ）释放减少。
The injury of bovine cerebromicrovessel endothelial cells(BCMEC) by 30% hydrogen peroxide
was investigated in culture. BCMECS were damaged by hydrogen peroxide at the concentration
3μmol/ml after 30 minutes incubation and the experiment showed that catalase and propylend
glycol mannate sulfate (PGMS) could protect BCMEC from damage induced by hydrogen
peroxide. The results suggested that the protective effects of PGMS on BCMEC injury may
probably play an important role in the potential use of cerebrovascular diseases.
出处
《山东医科大学学报》
1999年第1期82-84,共3页
Acta Academiae Medicinae Shandong
基金
山东省科委科研基金
关键词
甘糖脂
BCMEC
过氧化氢
脑血管疾病
保护作用
Propylene glycol mannate sulfate
Brain
Micrangium
Endothelial cell
Hydrogen peroxide
Cattle
