龙葵化学成分研究

Studies on the Chemical Constituents of Solanum nigrum

目的：研究茄属植物龙葵全草的化学成分。方法：采用硅胶、Sephadex LH-20及反相HPLC等色谱技术分离化学成分,通过理化性质和波谱数据分析鉴定化合物结构。结果：从龙葵氯仿部位得到6个化合物,分别鉴定为：（＋）-松脂素（Ⅰ）、（＋）-丁香脂素（Ⅱ）、（＋）-麦迪奥脂素（Ⅲ）、东莨菪内酯（Ⅳ）、二十四烷酸（Ⅴ）和β-谷甾醇（Ⅵ）。结论：化合物Ⅰ-Ⅲ为首次从该属植物中分离得到,化合物Ⅳ和Ⅴ为首次从该植物中分离得到。

Objective： To study the chemical constituents from Solanum nigrum.Methods： Compounds were isolated and purified by silica gel,Sephadex LH-20 and preparative HPLC.Their structures were identified by physicochemical properties and spectral analysis.Results： Six compounds were isolated and identified as（＋）-pinoresinol（Ⅰ）,（＋）-syringaresinol（Ⅱ）,（＋）-medioresinol（Ⅲ）,scopoletin（Ⅳ）,tetracosanoic acid（Ⅴ） and β-sitosterol（Ⅵ）.Conclusion： Compounds Ⅰ-Ⅲ are isolated from this genus for the first time,while compounds Ⅳ and Ⅴ are isolated from this plant for the first time.