摘要
用碱性氯化钠溶液提取和离子交换分离,从猪十二指肠中制得高抗血栓活性的类肝素。该组分在化学组成和性质上与肝素不同,葡萄糖醛酸和总硫酸基团含量低,抗凝血作用弱,抗血栓作用强,可明显改善微循环及调整血脂。
A kind of heparinoid with antithrombotic activity was
obtained from porcine duodenum by basic sodium chloride solution
extraction,followed by ion exchange with anion resin.The heparinoid is
different from heparin not only in chemical composition,such as lower
glucouronic acid(24.63±3.13%)and total sulfate content(15.07±2.82%),
but also in its higher antithrombotic and lower anticoagulant(72.9±6.0U/
mg)activities.
出处
《山东医科大学学报》
1990年第4期72-74,共3页
Acta Academiae Medicinae Shandong
关键词
抗血栓
类肝素
十二指肠
猪
Heparinoid
Duodenum
Swine
Ion exchange
Fibrinolytic agents
