摘要
本文采用海人酸（Ｋａｉｎｉｃａｃｉｄ，ＫＡ）诱发大鼠癫痫模型，结果表明，６、１０、１４ｍｇ／ｋｇ三种不同剂量的ＫＡ分别给大鼠腹腔注射，均能建立较好的癫痫模型；且随着ＫＡ剂量的增加，大鼠癫痫发作的潜伏期、发作时间均明显的缩短（Ｐ＜００１），但死亡率则增加。
Kainic acid(KA) was used in inducing epilepsy model in rats. The results showed that the model could be estalished by intraperitioneal injection of three doses of KA(6、10、14mg/kg), and it also showed the latent period and the time of seizure was significantly reduced ( P <0 01) and the dead rate was increasing.
出处
《实验动物科学与管理》
1999年第1期31-33,共3页
Laboratory Animal Science & Administration
关键词
大鼠
癫痫
海人酸
Rat\ Epilepsy\ Kainic acid.
