心肌病血清微量元素的研究

STUDY OF SERUM TRACE ELEMENTS IN CARDIOMYOPATHY

应用三电极直流等离子体-原子发射光电直读光谱仪测定了34例扩张型及肥厚型心肌病患者和34例正常人血清中的微量元素及铜锌比值,发现Zn、Cd在各组患者中均较对照组降低,A1则明显升高。Cu、Mn及Cu/Zn比值在扩张型心肌病组增高,Ca在肥厚型心肌病组升高。微量元素与肥厚型心肌病有无梗阻、扩张型心肌病有无心衰及心肌病的严重程度均无相关。

The serum trace elements:Cu,Zn,Cd,Mn,Al,Ca and the ratio of Cu/Zn were determined in 34 patients with hypertrophic and dilated cardiomyopathies and 34 normal controls.The results showed that serum levels of Zn and Cd were lower in patients with each type of cardiomyopathy than that of normal controls,serum Al were significantly higher,P<0.01.The levels of Ca were significantly higher in hypertrophic cardiomyopathy.In dilated cardiomyopathy,the levels of Cu,Mn and the ratio of Cu/Zn were clevated compared with normal controls.The leveIs of serum trace elements were not correlated with the severity of the disease.We reckoned that hyper- calcemia may be one of the etiologic factors in the pathogenesis of hyper- trophic cardiomyopathy.The elevation of Cu was unlikely to have any rela- tionships with the pathogenesis of DC,but rather represents a phenomenon or result of the evolution of the disease.