摘要
采用MTT法,以长春新碱(VCR)为阳性对照,研究了6种从菝葜属植物中分离提取的天然甾体皂甙化合物对肝癌SMMC-7721、人宫颈癌HeLa和胃腺癌MGc80-3细胞生长的抑制作用.结果显示;6种甾体皂甙抗肿瘤活性与其化学结构密切相关,对三种癌细胞的抑瘤作用强度相同,抑癌活性的顺序为:薯蓣皂甙>VCR>SQD_4>SQD_3>M_1>SQD_1,甲基原薯蓣皂甙.甾体骨架的差异性是决定这类化合物抗肿瘤活性的主要因素.
The antitumour activities of 6 natural steroidal saponins extracted from Smilax on hepatoma SMMC-7721 cell,human cervicarcinoma HeLa cell and human gastric adenocarcinoma. MGc80-3 cell vs well known antitumour drug, vincristine (VCR),were studied using the MTT colorimetric assay. The results showed that the antitumour effects of 6 steroidal saponins were related both to their chemical structures and to tumour cell lines susceptibities to tested compounds. The antitumour effects ranked as dioscin>VCR>DQD4>SQD3>M1>SQD1,methyl protodioscin. The steroidal structure of these steroidal saponins was the decisive factor for their antitumour activities.
出处
《天然产物研究与开发》
CAS
CSCD
1999年第1期14-17,共4页
Natural Product Research and Development
关键词
甾体皂甙化合物
菝葜
肝癌
人宫颈癌
胃腺癌
Steroidal saponins,Smilax,Hepatoma SMMC-7721,Human cervicarcinoma HeLa,Human gastric adenocarcinoma MGc80-3
