我国一例典型艾滋病家庭的确认及其病毒env基因片段的序列分析

CONFIRMATION OF A TYPICAL HIV INFECTED CHINESE FAMILY AND SEQUENCE ANALYSIS OF THE env GENE SEGMENT

报道一例我国典型的ＨＩＶ感染家庭，其中对新生儿通过垂直传播感染的早期诊断为我国首例报道。父亲通过静脉吸毒感染ＨＩＶ，经性途径传播给妻子，并通过母婴途径传播至婴儿，导致婴儿发病。通过血清学、ＰＣＲ检测和病毒培养确认了整个家庭的感染。序列分析结果强烈支持感染来自同一毒株，流行背景证实了上述感染的传播途径。

One typical HIV infected Chinese family was reported. The husband was HIV 1 infected by drug abuse and transmitted to his wife. Then the wife transmitted to their newborn by vertical transmission. Serum test, PCR test and viral culture confirmed their infection. Sequences of HIV env gene were analyzed. Laboratory data strongly indicate three infections were induced by one strain of HIV 1. The epidemiology investigation confirmed the pathway of transmission.