蝮蛇三龙丹胶囊对大鼠实验性脑血肿的影响

Study of the Effect of Agkistrodon haly Sanlongdan Capsule on Mice Experimental Cerebral Hematoma

目的探讨蝮蛇三龙丹胶囊对大鼠实验性脑血肿的影响。方法采用大鼠自体血液颅内注入造成大鼠脑血肿模型，观察蝮蛇三龙丹胶囊的作用。结果蝮蛇三龙丹胶囊（０．２ｇ／ｋｇ、０．４ｇ／ｋｇ）可明显降低脑指数、脑组织含水量（Ｐ＜０．０１）及Ｃａ２＋离子含量（Ｐ＜０．０１），对Ｎａ＋、Ｋ＋离子含量无明显影响（Ｐ＜０．０５）。结论蝮蛇三龙丹胶囊对实验性脑血肿诱发脑水肿有一定防治作用，且对小鼠出、凝血时间无影响，亦未见对大鼠实验性脑血肿发生再出血。本实验为蛇毒制剂治疗高血压性脑出血提供可靠依据。

Objective To probe into the effect of Agkistrodon haly Sanlongdan capsule on experimental imce cerebral hematoma Methods Setting up models by injecting the mice's brain with their own blood to induce massive cerebra hematoma, and then treat the mice with Agkistrodon haly Sanlongdan capsule Result With dosages of 0 2g/kg and 0 4g/kg, the capsules could significantly reduce cerebral exponents, with the water content of cerebral tissues of P<0 01 and Ca ion contents P<0 01, but didn't show obvious effect on contents of Na and K ions ( P<0 05 ) Conclusion Agkistrodon haly Sanlongdan has therapeutic and preventive effect on cerebra edema induced by experimental cerebral hematoma