蛇岛牌精制蝮蛇抗栓酶治疗Ⅱ型糖尿病并脑梗死

Therapeutic Effect of “Shedao” Agkistrodon halys Antithrombin Enzyme in Treatment of Cerebra Infarction Induced by Diabetes Ⅱ

目的观察蛇岛牌精制蝮蛇抗栓酶对Ⅱ型糖尿病并脑梗死的疗效。方法各选择１３５例Ⅱ型糖尿病并脑梗死患者为治疗组和对照组，两组患者既往史和伴发病积分无显著差异。两组均在起病后６～７２ｈ开始治疗。治疗组：用精制蝮蛇抗栓酶首剂３．０ＩＵ，每日１次，连续使用３次，隔日改为１．０ＩＵ治疗１０次，每疗程为１４天。对照组：低分子右旋糖酐５００ｍｌ，每日１次，共１４次。治疗中行凝血指标测定、颅ＣＴ、血流变检查及副作用观察，然后进行统计学处理。结果治疗后，神经功能评分，血流变有显著差异，治疗组疗效优于对照组，无副作用。且对糖尿病并发症有很好的治疗作用，但与无糖尿病脑梗死者相比疗效略差。结论精制蝮蛇抗栓酶治疗糖尿病并脑梗死优于低分子右旋糖酐对照组，对肾脏无损害。

Objective To investigate the therapeutic effect of “Shedao”Agkistrodon halys antithrombin enzyme in treatment of cerebra infarction induced by diabetes Ⅱ Methods Patients with similar case history were selected and divided into two groups, with each consisting of 135 Both group starte treatment after the occurrence of the disease within 6￣72h The experimented group were given 3 0IU of the Agkistrodon halys antithrombin enzyme each patient daily for the first time three days continually Then each patient received 1 0IU per time for ten times continually The therapeutic course lasted 14d The control group were treated with 500ml of dextran each daily for 14 times During the treatment, coagulation measurement, brain CT, blood flow detection and side effect examinations were conducted statistically Results The experimented group showed better improvement in blood flow than the control without side effect and had good therapeutic effect on diabetes complications, but less effectiveness on non diabetes cerebra infarction Conclusion The above mentioned antithrombin show better therapeutic effect on patients of cerebra infarction induced by diabetes Ⅱ than dextran, and has no damage to the kidneys