肽酰基精氨酸脱亚氨酶4检测方法的研究进展
摘要
肽酰基精氨酸脱亚氨酶4(PAD4)催化蛋白质分子中精氨酸残基脱亚氨基,产生含瓜氨酸的蛋白质。瓜氨酸化蛋白质与类风湿性关节炎(RA)发病机制有关,PAD4被认为是治疗RA的新靶酶,检测PAD4对研究RA早期诊断方法与筛选RA治疗新药有意义。目前,用于检测分析PAD4的方法有二乙酰一肟比色法、高压液相层析法、连续分光光度监测法、ABAP测定法、荧光标记ABPP测定法等。
出处
《国际检验医学杂志》
CAS
2010年第5期468-469,472,共3页
International Journal of Laboratory Medicine
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