鱼类斯钙素的研究进展

ADVANCES IN THE RESEARCH OF STANNIOCALCIN PRODUCED BY THE CORPUSCLES OF STANNIUS IN TELEOST

本文概述了近年来有关硬骨鱼类斯坦尼氏小体（ｃｏｒｐｕｓｃｌｅｓｏｆＳｔａｎｎｉｕｓ，ＣＳ）分泌激素———斯钙素（ｓｔａｎｎｉｏｃａｌｃｉｎ，ＳＴＣ）的研究进展。ＳＴＣ是糖蛋白类激素，为同型二聚体，其表观分子量在天然状态下从４６（大麻哈鱼）～５６（虹鳟）ｋＤａ，还原状态下则为２３～２８ｋＤａ。ＳＴＣ单体的氨基酸序列分析表明，大麻哈鱼、银大麻哈鱼和澳大利亚鳗鲡的氨基酸残基数分别为１７９、２２３和２３１个。研究还表明，ＳＴＣ的分泌受血钙浓度的调节，并且胆碱能神经参与ＳＴＣ的释放。

This paper reviewed the recent researches on the stanniocalcin (STC) produced by the corpuscles of Stannius in teleost.STCs are homodimeric glycoprotein hormones with apparent molecular weight ranging from 46kDa(chum salmon)to 56kDa (rainbow trout) in native form and 23-28kDa in the reduced condition.The amino acid sequence analyses of STCs and cDNAs have revealed that reduced STCs (monomer) consist of 179 (chum salmon),223 (coho salmon) and 231 (Australian eel) amino acid residues,respectively.Other studies show that secretion of STC is regulated by calcium concentrations and that the cholinergic nerves are involved in the release of STC.