生存素和磷酸酶基因在胃癌中的表达

Significance of Survivin and PTEN in gastric cancer development and correlation between Survivin and PTEN

目的 探讨生存素（Survivin）和磷酸酶基因（PETN）与胃癌的关系及两者的相关性.方法 采用免疫组化的方法检测105例胃癌病理标本中Survivin、PETN的表达情况,并与98例阴性胃黏膜组织中Sur-vivin、PETN的表达情况比较.结果 胃癌组织标本中Survivin表达阳性率为82.9%（87/105）,非胃癌组织标本中Survivin表达阳性率为6.1%（6/98）,两者差异有统计学意义（P〈0.01）;胃癌组织标本中PETN表达阳性率为34.3%（36/105）,非胃癌组织标本中PETN表达阳性率为99.0%（97/98）,两者差异有统计学意义（P〈0.01）.胃癌组织中Survivin、PETN的表达与患者的性别无关（P〉0.05）,而与肿瘤细胞分化程度、浸润深度、淋巴结转移、远处脏器转移及TNM分期有关（P〈0.05）.Survivin与PETN呈负相关（r=-0.23.P〈0.05）.结论 胃癌的发生与Survivin的异常高水平表达及PTEN的表达缺失有关;胃癌组织中Survivin、PEIN的表达情况与患者的性别无关,而与肿瘤细胞的分化程度、浸润深度、淋巴结转移、远处脏器转移及TNM分期有关;Survivin与PETN的表达呈负相关关系.

Objective To explore the significance of Survivin and PTEN in gastric cancer development and correlation between Survivin and PTEN.Methods Immunohistochemical methods were applied to detect the expres.sion of Survivin and PTEN in 105 pathological specimens of gastric cancer, in comparison to that in 98 negative gastric mucosa tissues.Results The positive rate of Survivin expression was 82.9% （87/105） in tissue specimens of gastric cancer and 6.1% （6/98） in tissue specimens of non-gastric cancer;The difference between them was statistically sig nificant （P 〈0.01）.The positive rates of PTEN expression were 34.3% （36/105） in tissue specimens of gastric canc-er and 99.0% （97/98） in tissue specimens of non-gastric cancer;The difference between them was statistically signifi-cant （ P 〈0.01）.The expression of Survivin and PTEN in tissues of gastric cancer had nothing to do with the gender of patients （ P 〉 0.05 ） , but was correlated with the degree of tumor cell differentiation, depth of invasion, lymph node me-tastasis, distant organ metastasis and TNM staging（P 〈0.05）.Analysis by Spearman showed that Survivin was nega-tively correlated with PTEN（ r = -0.23 ,P 〈 0.05 ）.Conclusion The incidence of gastric cancer was related to the abnormally high level of Survivin expression and absence of PTEN expression;The expression of Survivin and PTEN in tissues of gastric cancer was unrelated with the gender of patients, but related to the degree of tumor cell differentia-tion, depth of invasion,lymph node metastasis,distant organ metastasis and TNM staging.The expression of Survivin was negatively correlated with the expression of PTEN.