不同方案治疗卵巢上皮性癌的疗效比较

Therapeutic effect of different treatment progarams for epithelial ovarian cancer

目的 探讨不同方案治疗卵巢上皮性癌的临床疗效.方法 选择卵巢上皮性癌患者共265例,分为A、B两组,就其手术方式、化疗方案及疗效进行比较.两组手术方式基本相同,A组采用PAC化疗方案,B组采用TC方案.结果 两组肿瘤残留病灶直径〉2 cm者分别占29.2%、14.2%,临床缓解率、部分缓解牢差异无统计学意义,有效率分别为51.7%、81.4%（P〈0.05）.A组的1、2、3、4、5年生存率分别为90.2%、86.9%、62.7%、45.8%、32.7%,中位生存期和无复发生存期分别为37.9个月和17.4个月;B组的1、2、3、4、5年生存率分别为94.3%、91.1%、68.7%、56.4%、44.2%,中位生存期、无复发生存期分别为50.5个月和32.2个月;两组5年生存率、中位生存期、无复发生存期间差异有统计学意义（P〈0.01或〈0.05）.结论 手术残留病灶的大小及化疗方案影响卵巢上皮性癌的疗效,TC化疗方案优越于PAC化疗方案.

Objective To explore different methods on the efficacy of epithelial ovarian cancer.Methods The patients with epithelial ovarian cancer,a total of 265 cases,who was treated were selected and divided into A,B groups.Its surgical,chemotherapy and efficacy were compared.It was basically the same between the two surgical.On chemotherapy,A group was given PAC program mainly,B group Was given TA program mainly.Results Diameter of residual tumor lesions〉2 cm respectively accounted for 29.2%.14.2%.The difference of clinical remission rate,partial remission rate was not significant.Effective rates were respectively 51.7% and 81.4%（P〈0.05）.To group A,the survival rates of 1-year,2-years,3-years,4-years,5-years were respectively 90.2%,86.9%,62.7%,45.8%,32.7%：The median survival period and relapse-free survival time was respectively 37.9 months and 17.4 months.To group B,the survival rates of 1-year,2-years,3-years,4-years,5-years were respectively 94.3%、91.1%、68.7%、56.4%、44.2%;The median survival period and relapse-free survival time wag respectively 50.5 months and 32.2 months.The difference of 5-years survival rate,median survival,relapse-free survival of the two groups was statistically significant（P〈0.01 or 0.05）.Conclusions The size of postoperative residual disease and the chemotherapy im-paeted the efficacy of epithelial ovarian cancer.TC chemotherapy was superior to PAC chemotherapy.