脑心通对急性冠脉综合征患者血脂及超敏C反应蛋白的影响

Effect of Naoxintong on Serum Lipid Level in Patients with Acute Coronary Syndrome

目的 探讨脑心通辅助治疗对急性冠状动脉综合征（ACS）患者血脂水平等的影响.方法 将82例ACS患者随机分为观察组（阿托伐他汀＋脑心通）和对照组（辛伐他汀）,分别检测两组患者服药前和服药8周后的血清超敏C反应蛋白（hs-CRP）、血脂（TC、TC、LDL-C、HDL-C）水平.结果 治疗8周后,观察组患者血清hs-CRP（5.63±1.38）mg/L、TC（4.21±0.87）mmol/L、TG（1.99±0.48）mmol/L、LDL-C（2.71±0.83）mmol/L明显低于对照组[hs-CRP（6.83 ±1.46）mg/L、TC（4.89±0.91）mmol/L、TG（2.58±0.52）mmol/L、LDL-C（3.28±0.89）mmol/L],HDL-C（1.89±0.47）mmo[/L明显高于对照组（1.63±0.45）mmol/L（t为2.55～4.36,P〈0.01～0.05）.结论 脑心通辅助治疗,能明显改善ACS患者血脂和血清hs-CRP水平,对急性冠脉综合征患者有较好的治疗效果.

Objective To investigate the effects of atorvastatin combined with Naoxintong capsules on serum lipid level and hish sensitivity C-reactive protein（hs-CRP）in patients with acute coronary syndrome（ACS）.Methods 82 ACS patients were randomly divided into observation group（10 mg/d of atorvastatin and 4 capsules 3 times of Naoxintong daily,n=41） and control group（20 mg/d of simvastatin daily,n=41）.The levels of serum lipid and hs-CRP were detected before and after treatment.Results 8 weeks after treatment,the levels of serum hpid[TC （4.21±0.87）mmol/L,TG（1.99±0.48）mmol/L,LDL-C（2.71±0.83） mmol/L] and serum hs-CRP（5.63±1.38）mg/L in observation group were significantly lower than those in control group[TC（4.89±0.91）mmol/L,TG （2.58±0.52）mmol/L,LDL-C（3.28±0.89）mmol/L],and serum level HDL-C（1.89±0.47）mmol/L was higher than that in control group（1.63±0.45）mmol/L（t=2.55-4.36,P〈0.01～0.05）.Conclusion Adjuvant therapy of Naoxintong could promote the levels of serum lipid and hs-CRP in patients with ACS.and offer a better therapeutic effect in these patients.