婴幼儿病毒性肺炎165例病原学分析

Etiology analysis of 165 infant patients with viral pneumonia

目的 了解婴幼儿病毒性肺炎的病原学概况与临床特点.方法 应用间接免疫荧光法（IIF）检测婴幼儿肺炎患儿急性期血清11种病毒[呼吸道合胞病毒（RSV）,腺病毒（ADV）,流感病毒（IFV-A＋B）,副流感病毒（PIVt-4）,柯萨奇B1病毒（CB1V）,柯萨奇A7病毒（CA7V）,埃可病毒]特异性抗体IgM,按血清病毒特异性IgM阳性,C反应蛋白（CRP）〈8 mg/L且无其他病原学感染的临床及实验室证据为条件检测436例肺炎患儿.结果 检出总抗体阳性165例,阳性检出率为37.99%.其中单一病毒感染103例,占82.4%,混合感染22例,占17.6%.RSV感染居首位,其余依次为IFV、ADV和PIV.婴幼儿不同年龄段,不同季节易感病毒的种类不同.结论引起婴幼儿肺炎的病原除细菌外,病毒感染的种类繁多,其发病的年龄、流行季节与临床表现各异.

Objective To comprehend etiology and clinical manifestation changes of infant pneumonia in this locality.Methods Indirect immunofluorescence （IIF） assay was applied in children with acute pneumonia to detect serum 11 kinds of viruses[respiratory syncytial virus （RSV）,adenovirus （ADV）,influenza virus （IFV-A＋B）,parain fluenza virus（PIV14） ,coxsackie B,virus（CB1V）,Coxsackie A7 virus （CA7V） ,ECHO virus]specific antibody IgM,according to the serum virus-specific IgM positive,C-reactive protein（CRP）〈8mg/L and no other pathogenic infection and laboratory evidence for the conditions of 436 cases detected in children with pneumonia.Results Detected a total 125 cases of antibody-positive,the positive detection rate is 37.99%.Of which 103 cases of single virus infection .accounting for 82.4% ,22 cases of mixed infection,accounting for 17.6%.RSV infection on top of the list followed by the rest of IFV,ADV and PIV.Infants of different ages,different seasons of the different types of virus susceptibility.Conclusion Pneumonia in infants were caused by pathogenic bacteria in addition to the virus of a wide range,and the incidence of age,the peak seasons and the clinical manifestations were vary.From an early stage of infection pathogen detection,clearing pathogen type,making the correct diagnosis of pneumonia in the treatment of infants had an important guiding significance.