消旋卡多曲治疗婴幼儿急性水样泻112例疗效观察

Effects of racecadotril on acute diarrhea in 112 infants

目的:观察消旋卡多曲颗粒治疗婴幼儿急性水样泻的疗效及安全性。方法:对我院门诊2008年10月—2009年5月的112例急性水样泻患儿,随机分成观察组和对照组,对照组予蒙脱石散、妈咪爱、补液等综合治疗,观察组在此基础上加用消旋卡多曲颗粒1.5mg·kg-1治疗,tid,治疗3d后开始观察疗效。结果:治疗组总有效率92.8%(52/56),显著高于对照组78.6%(44/56),差异有统计学意义(χ2=7.56,P<0.01);观察组平均治疗时间(3.4±0.7)d,对照组平均治疗时间(4.7±1.0)d,两组比较差异有统计学意义(t=8.25,P<0.01)。结论:消旋卡多曲治疗婴幼儿急性水样腹泻,可明显缩短病程,疗效显著,且未发现与药物有关的不良反应,安全性好。

OBJECTIVE To observe the effect and security of racecadotril granules on acute diarrhea in infants. METHODS 125 cases of infants with acute diarrhea hospitalized from October 2008 to May 2009 were divided randomly into treatment group and control group. The infants in the control group accepted comprehensive treatment with Smectite powder, Medilac-Vita and fluid replacement ,etc. The treatment group was added with racecadotril granules, with a dosage of 1.5 mg·kg^-1, three times a day. The curative effect and total efficiency were observed three days later. RESULTS The total effective rate of the treatment group was 92. 8% （52/56）, significantly higher than that 78.6%（44/56） in the control group （P〈0. 05）. CONCLUSION Racecadotril can significantly shorten the course of disease. The curative effect of racecadotril granules for acute diarrhea in infants is significant and safe, without adverse effects found.