缺血性中风急性期证型与血管假性血友病因子血栓素B_2及6-酮-前列环素F_(lα)的相关性研究

Clinical Research on the Relationship Between the TCM Syndrome and vWF,TXB_2 and 6 - Keto - PGF_(lα) in Acute Cerebral Ischemic Stroke

目的:通过对vWF、TXB2与6-Keto-PGFlα水平与缺血性中风急性期中医证型的临床观察,为缺血性中风急性期中医辨证分型提供客观依据,指导临床的辨证分型。方法:选取缺血性中风急性期患者90例,中医辨证分型为气虚证、痰证、血瘀证各30例,选取健康对照组30例,测定各组患者血浆中vWF、TXB2、6-Keto-PGFlα的含量。结果:与正常对照组比较,各证型缺血性中风患者血浆vWF、TXB2水平均明显升高(P均<0.01),6-Keto-PGFlα水平明显降低(P均<0.01);3个不同的中医证型间,vWF水平血瘀证高于气虚证及痰证(P<0.01),气虚证与痰证间无显著性意义;TXB2水平血瘀证>痰证>气虚证(P均<0.01);6-Keto-PGFlα水平气虚证低于痰证(P<0.01),气虚证低于血瘀证(P<0.05),痰证与血瘀证间无显著性意义。结论:血浆vWF、TXB2及6-Keto-PGFlα水平与缺血性中风急性期中医辨证分型有一定的相关性。

Objective： To investigate the correlation between plasma von Willebrand factor（ vWF） ,Thromboxane（ TXB2） ,6-keton-prostaglandin（ 6-Keto-PGFlα） and differential traditional Chinese medicine（ TCM） syndromes of Acute Cerebral Ischemic Stroke.Methods： Selecting 90 cases of Acute Cerebral Ischemic Stroke,there are 30 cases of qi deficiency syndrome,30 cases of phlegm syndrome and 30 cases of blood stasis syndrome according to Syndrome Differentiation of TCM,and selecting 30 cases of the normal group.The concentration of plasma vWF,TXB2 and 6-Keto-PGFlα was tested respectively.Results： Compared with the normal group,the concentration of plasma vWF and TXB2 were significantly increased（ P 0.01） and the concentration of plasma 6-Keto-PGFlα were significantly decreased（ P 0.01） in the group of Acute Cerebral Ischemic Stroke.Compared with the syndromes of qi deficiency and phlegm,the concentration of plasma vWF were significantly increased（ P 0.01） in blood stasis syndrome,there are no significant differences in qi deficiency syndrome and phlegm syndrome.In the concentration of plasma TXB2,the blood stasis syndrome is higher than the phlegm syndrome（ P 0.01） ,the phlegm syndrome is higher than the qi deficiency syndrome（ P 0.01） .In the concentration of plasma 6-Keto-PGFlα,the qi deficiency syndrome is lower than the phlegm syndrome（ P 0.01） ,the qi deficiency syndrome is lower than the blood stasis syndrome（ P 0.05） ,there are no significant differences in the phlegm syndrome and the blood stasis syndrome.Conclusion： There are correlations between plasma vWF,TXB2,6-Keto-PGFlα and differential TCM syndromes in Acute Cerebral Ischemic Stroke.