复方硫磺洗剂与红霉素联合治疗痤疮的疗效观察

Efficacy Observation of Compound Sulfur Lotion Combined with Erythromycin in the Treatment of Acne

目的:观察复方硫磺洗剂与红霉素联合用药治疗痤疮的疗效。方法:100例痤疮患者按严重程度分为轻、中、重度,按双盲设计要求,随机分为2组,每组各50例:对照组给予外用复方硫磺洗剂,该洗剂由本院制剂室配制,处方配制按照《中国医院制剂规范》规定执行;治疗组给予外用复方硫磺洗剂联合红霉素,所用药物为每100mL复方硫磺洗剂加入6支红霉素无菌粉末(共1.5g)。4周为1疗程,每周复诊或随访1次,并观察记录患者粉刺、炎性丘疹、脓包和结节囊肿个数。结果:复方硫磺洗剂与红霉素联合治疗痤疮的总有效率(76%)明显高于对照组(38%),2组比较有显著性差异(P<0.05),且在治疗过程中不良反应发生率较低。结论:复方硫磺洗剂联合红霉素治疗痤疮疗效较好,副作用较少,且用药方便。

OBJECTIVE：To observe efficacy of compound sulfur lotion combined with erythromycin in the treatment of acne.METHODS：100 patients with mild,moderate and severe acne were randomly divided into control group（n=50） and treatment group（n=50）.Control group were treated with sulfur lotion for external use,and treatment group were given compound sulfur lotion and erythromycin for external use for 4 weeks.Each compound sulfur lotion 100 mL combined with 6 piece of erythromycin（a total of 1.5 g）.Return and follow-up visit were performed once a week.The number of acne,imflammatory papule,pustule,node cyst were observed and recorded.RESULTS：Total response rate of treatment group was 76%,which was significantly higher than that of control group（38%）.There were statistical difference between 2 groups（P0.05）.There was low incidence of ADR during treatment.CONCLUSION：Compound sulfur lotion combined with erythromycin shows sound effect on acne with few side effects and medication convenience.