3种抗菌药物治疗急性结石性胆囊炎的成本-效果分析

Cost-effectiveness Analysis of 3 Kinds of Antimicrobial Drugs for Acute Lithiasic Cholecystitis

目的:评价3种抗菌药物治疗急性结石性胆囊炎的经济学效果,为临床胆道外科手术合理使用抗菌药物提供参考。方法:采用多中心前瞻性临床对照研究,将493例急性结石性胆囊炎患者随机分为A组180例(头孢哌酮舒巴坦钠组)、B组148例(头孢呋辛组)、C组165例(左氧氟沙星组),运用药物经济学方法进行分析。结果:A、B、C组的治疗有效率分别为95.56%、73.65%、84.24%,成本分别为17845.81、14496.86、16196.25元,成本-效果比分别为186.75、196.83、192.26,A、C组方案相对于B组方案的增量成本-效果比分别为145.72、160.47。结论:与B、C组的方案比较,A组方案治疗急性结石性胆囊炎较经济。

OBJECTIVE：To evaluate economic effectiveness of 3 kinds of antimicrobial drugs for acute lithiasic cholecystitis,and to provide reference for rational use of antimicrobial drugs in biliary disease surgery.METHODS：A multicenter prospective randomized controlled study was conducted in 493 clinical cases of acute lithiasic cholecystitis.Cost-effectiveness analysis of cefoperazone/sulbactam sodium（therapy A n=180）,cefuroxime（therapy B n=148） and levofloxacin（therapy C n=165） for acute lithiasic cholecystitis were carried out.RESULTS：Effective rates of three kinds of therapeutic regimens 95.56%,73.65%,84.24%,respectively.CONCLUSION：Incremental cost-effectiveness analysis of three kinds of therapeutic regimens shows therapy A is economical and the best choice for acute lithiasic cholecystitis compared with group B and C.