伊维菌素对雄性大白鼠生育功能的影响

Effects of Ivermectin on Male Rats Procreation

探讨伊维菌素对雄性动物生殖功能的影响,为临床用药安全和动物繁殖提供依据。试验选取成年雄性大白鼠,按照0.17mg/kg(低剂量组),3mg/kg(中剂量组),5mg/kg(高剂量组)的剂量分别进行灌胃,对照组以生理盐水代替药物进行灌胃。末次给药后24h处死大鼠,取睾丸、附睾进行生殖系统毒性检查。试验结果表明:当伊维菌素用药剂量达到3mg/kg以上就呈现出一定的生殖毒性,睾丸系数、附睾系数下降,精子密度和精子活率下降,但对精子活力并没影响,4个试验组均未显示与剂量的相关性。

This experiment was based on investigating the reproductive function of male animals treated with Ivermectin,in order to provide the basis for clinical safe medication and animal breeding.We chose the adult male rats as the experimental model,all of them were divided into 0.17 mg/kg（low dose group）,3 mg/kg（middle dose group）and 5 mg/kg（high dose group）groups,which were fed with Ivermectin of the corresponding dose,and control group was fed with saline instead of ivermectin.After 24 hours of the last administration,all the rats were executed to take testis and epididymis for analyzing the toxicity of the reproductive system.The results showed that there was a reproductive toxicity on testis and epididymis when the dose of ivermectin was over 3 mg/kg;Testis coefficient and epididymis were affected,such as the density and alive rate of the sperm were decreased,but the sperm viability was not influenced,and no results showed correlation with Ivermectin dosage in all groups.