硝酸甘油治疗小儿重症肺炎心力衰竭的临床研究

Clinical study on Nitroglycerin treatment of children with heart failure and severe pneumonia

目的:通过应用硝酸甘油治疗小儿重症肺炎心力衰竭(简称心衰),探讨更为经济有效的治疗方法。方法:选取70例重症肺炎心衰患儿,其中包括左向右分流的先天性心脏病患儿,随机分为对照组和治疗组,两组均常规抗感染、利尿、强心、吸氧,治疗组加用硝酸甘油输液泵维持。比较两组在48、96h的治愈率及两组治疗后症状(气促、肺部啰音)缓解所需时间。结果:两组在48、96h的治愈率比较,差异均有统计学意义(P<0.05或P<0.01);两组治疗后症状缓解所需时间比较,差异有统计学意义(P<0.01)。结论:小儿重症肺炎心衰时应用硝酸甘油输液泵均匀持续给药,对心衰的缓解以及肺炎原发病的恢复效果明显优于单纯常规治疗。

Objective：To explore the more cost-effective treatment through the application of Nitroglycerin treatment of children with heart failure and severe pneumonia.Methods：70 children with severe pneumonia and heart failure were selected,including left to right shunt congenital heart disease,and they were randomly divided into control group and treatment group,the two groups were treated with conventional anti-inflammatory,diuretic,strong heart,oxygen,and the treatment group plus Nitroglycerin infusion pump to maintain.The cure rate of two groups at 48,96 hours,and the symptoms（short breath,pulmonary rales） remission time of two groups after treatment were compared.Results：The cure rate of two groups at 48,96 hours were compared,the differences were statistical significance（P0.05 or P0.01）;the symptoms remission time of two groups after treatment were compared,the differences were statistical significance（P0.01）.Conclusion：Children with severe pneumonia and heart failure in the application of uniform continuous nitroglycerin infusion pump delivery,to alleviate heart failure and pneumonia recovery of the original disease is better than conventional treatment.