抗结核药致药物性肝病37例临床分析

Anti-tuberculosis drugs induced liver disease drug clinical analysis of 37 cases

目的:总结抗结核药所致DILD的临床特点,提高对抗结核治疗引起DILD的认识,探讨其预防和治疗。方法:采用回顾性调查方法对我院收治的49例由抗结核药物所致DILD患者临床特点和各项检查进行分析。结果:①临床表现不同。②临床分型以急性多见。③多种危险因素如年龄、合并症、联合用药等对DIHD发生起作用。结论:重视和监测抗结核治疗引起的肝功能损害,对发生DIHD者要及早停药保肝治疗。

Objective：To summarize the anti-tuberculosis drugs induced DILD clinical features,anti-tuberculosis treatment-induced DILD raise awareness of the prevention and treatment.Methods：Retrospectively investigate on 49 cases in our hospital due to DILD by the anti-TB drugs in patients with clinical features and analysis of the inspection.Results：① The different clinical manifestations.②Acute was the prevalent clinical type.③Multiple risk factors such as age,complications occur in combination and so on were connected with the occurrence of DIHD.Conclusion：The attention and monitoring of anti-TB treatment-induced liver damage on those who happen to be an early withdrawal DIHD hepatoprotective treatment.