驻南方某部军人胃食管反流病的流行病学研究

Epidemiological survey of gastroesophageal reflux disease in troops stationed in southern China

目的探讨军人胃食管反流病(GERD)的发病情况及相关危险因素。方法采用整群分层随机抽样方法 ,对驻南方某部军人进行GERD临床表现及危险因素问卷调查。按反流性疾病问卷(RDQ)评分定义,对胃灼热、反酸、反食、非心源性胸痛等GERD典型临床表现进行评分,根据其严重程度和频次进行评分,计算出每位被调查者的总积分(Sc),Sc≥12分列入病例组,Sc<12列入非病例组。结果共选取驻南方某部军人2400余人进行调查,获得有效调查问卷2000份,GERD临床表现发生率为5.10%,以炮兵最高,武警最低,但不同兵种间无显著差异(P>0.05)。病例组腹胀、嗳气、恶心、呕吐、腹痛等的发生率及喉炎、咽炎、口腔溃疡等疾病的发生率均高于非病例组(P<0.05),饮酒、高脂饮食、进食过饱、辛辣饮食、饮浓茶、便秘等的比例也高于非病例组(P<0.01)。年龄(OR=1.112)、高脂饮食(OR=1.136)、进食过饱(OR=1.765)、辛辣食物(OR=1.575)、浓茶(OR=1.760)、便秘(OR=3.154)、压力(OR=1.085)与GERD临床表现发生的关系较大,兵种、体重指数(BMI)、抽烟、饮酒、甜食、咖啡等与GERD发生的无明显关系。结论军人GERD患病率与亚洲普通人群相似,且临床表现的发生与多种因素密切相关。

Objective To assess the prevalence and related factors of gastroesophageal reflux disease （GERD） in troops stationed in southern China. Methods An investigation with validated questionnaire and stratified random sampling method was carried out in troops stationed in southern China to survey the prevalence of GERD and its related factors. According to the definition of reflux disease questionnaire （RDQ） score,the severity and frequency of the dominant symptoms of GERD,such as heartburn,acid regurgitation,food reflux and non-cardiogenic chest pain were scored. People with score equaled to and higher than 12 （Sc≥12） were assigned to patient group,and those with score lower than 12 （Sc12） to control group. Results A total of 2000 soldiers were enrolled into this investigation. The prevalence of GERD was 5.10%,with highest incidence in artillerymen,and lowest in armed policemen,but no significant difference was found among servicemen in different services （P0.05）. Subjects in the patient group had a higher incidence of abdominal distension,belching,nausea,vomiting,abdominal pain compared with control group. A higher incidence of laryngitis,pharyngitis and ulcerative stomatitis （P0.05） existed also in patient group. Habit of drinking,high fat diet,over eating,use of spicy food,strong tea and constipation were more prevalent in this group （P0.01）. The prevalence of GERD was correlated with age （OR=1.112）,high fat diet （OR=1.136）,over eating （OR=1.765）,spicy food （OR=1.575）,strong tea （OR=1.760）,constipation （OR=3.154） and stress （OR=1.085）,while not correlated with different army services,BMI,smoking,drinking,confection and coffee. Conclusions The prevalence of GERD in troops stationed in southern China is similar to that of the general population,and it is related to many factors.