胶质瘤染色体1p/19q联合缺失特点分析

Characteristics of combining loss of heterozygosity of 1p/19q in glioma

目的 研究胶质瘤1p/19q联合缺失与患者性别、年龄、肿瘤部位及病理分型是否具有相关性.方法 用荧光原位杂交法（Fluorescence in situ hybridization,FISH）对2009年1月至12月的138例胶质细胞瘤患者术后胶质瘤标本进行1P和19q缺失状态分析,男性80例,女性58例;年龄17～68岁,平均41.6岁.利用X2检验分析不同性别、年龄、肿瘤部位、病理类型的1p/19q联合缺失是否有差异.结果 星形细胞肿瘤（22.2%）的1p/19q联合缺失率显著低于少枝胶质细胞肿瘤（81.3%）和少枝星形细胞肿瘤（55.8%）（P＜0.01）,少枝胶质细胞肿瘤的1p/19q联合缺失率高于少枝星形细胞肿瘤（P＜0.05）.额叶胶质瘤的1p/19q联合缺失率（61.8%）显著高于颢叶（31.8%）和岛叶（34.6%）（P＜0.05）.1p/19q联合缺失与患者的性别、年龄无明显相关性.结论 1p/19q联合缺失主要与胶质瘤的病理类型和部位相关,与患者的年龄和性别无明显相关性.

objectives To find possible factors correlated with combined loss of heterozygosity （LOH）of 1 P and 19q.Methods The status of 1 P and 19q of 138 glioma specimen from January 2009 to December 2009 was evaluated by Fluorescence in situ hybridization（FISH）method,and the frequencies of combining LOH of 1 p/19q were compared between different pathologies,brain sub-regions,genders and ages.Results The frequencies of combined LOH of 1P and 19q of oligodendroglial（81.3%）and oligoastrocytic tumors（55.8%）were significantly higher than that of agtrocytic tumor（22.2%）（P＜0.01）,and the frequency of oligodendroglial tumor was significantly higher than that of oligoastrocytic tumor （P＜0.05）.The frequency of combining LOH of 1P and 19q in frontal lobe（61.8%）was higer than that in temporal（31.8%）and insular lobes（34.6%）（P＜0.05）.Conclusion Combining LOH of 1P and 19q has significant correlation with the pathologies and brain sub-regions.