期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

HBx在原发性肝癌发生中的作用研究进展 被引量：9

Role of HBx in hepatocellular carcinoma development
下载PDF
导出
摘要 肝癌是我国最常见的恶性肿瘤之一,而乙型肝炎病毒感染是引起肝癌的最主要原因。作为乙肝病毒X基因的表达产物HBx蛋白具有广泛的反式激活功能,其能通过直接或间接的蛋白质间相互作用参与感染肝细胞的信号转导、细胞凋亡和细胞周期调控。鉴于HBx蛋白在乙型肝炎病毒复制和在感染肝细胞中的重要作用,HBx蛋白在肝癌发生中扮演的角色及其作用机理研究,一直是HBV和肝癌研究的热点内容。 Hepatocellular carcinoma（HCC） is one of the most common malignant tumors in China,which is mainly caused by hepatitis B virus（HBV） infection.The X gene product（HBx） of HBV has extensive trans-activating functions.HBx affects the signal transduction,apoptotic cell death and cell cycle through interaction with variety intracellular proteins in infected hepatocytes.In view of the importance of HBx in HBV replication and in hepatic cell functions,the role of HBx in HCC development has been attracting great attention.
作者 项文清 刘伟
机构地区 浙江大学医学院生物化学与分子生物学系
出处 《浙江大学学报（医学版）》 CAS CSCD 北大核心 2010年第3期333-338,共6页 Journal of Zhejiang University(Medical Sciences)
基金 国家科技重大专项"十一五"课题资助项目(No.2008ZX10002-007)
关键词 肝肿瘤 病毒蛋白质类/遗传学 肝炎病毒 乙型/遗传学 Liver neoplasms Viral Proteins/genet Hepatitis B virus/genet
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献31

  • 1HENKLER F,HOARE J,WASSEM N,et al.Intracellular localization of the hepatitis B virus HBx protein[J].J Gen Virol,2001,82:871.
  • 2VICTOR V K,AMANDA J H,HARLES R M,et al.Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo[J].J Virol,2007,81:2656-2662.
  • 3HONG T,LUVSANJAV D,FEIJUN H,et al.The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication[J].J Virol,2005,79:5548-5556.
  • 4MICHAEL J B,WANG L H,ROBERT J S.Activation of focal adhesion kinase by hepatitis B virus HBx protein:multiple functions in viral replication[J].J Virol,2006,80:4406-4414.
  • 5KEALSER V V,AMANDA J H,CHARLES R M,et al.Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice[J].Virol,2009,390:122-129.
  • 6KIM S Y,KIM J C,KIM J K,et al.Hepatitis B virus X protein enhances NFκB activity through cooperating with VBP1[J].BMB reports,2008,41:158-163.
  • 7TANAKA Y,KANAI F,ICHIMURA T,et al.The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1[J].Oncogene,2006,25:633-642.
  • 8DELPHINE C,WU Y F,STEFANO C,et al.The hepatitis B Virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription[J].J Biol Chem,2007,282:2477-4287.
  • 9章莉,郑大利,黄健,韩泽广.HBx基因转染对Huh7细胞中基因转录的影响[J].肿瘤,2008,28(4):282-287. 被引量：4
  • 10AMY J C,TRICIA L G,MICHAEL J B.Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-κB and the mitochondrial permeability transition pore[J].J Virol,2009,83:4718-4731.

二级参考文献24

  • 1易石坚,钟德玝,杨竹林.金属硫蛋白在肝细胞癌中的表达及其临床意义[J].南华大学学报（医学版）,2006,34(4):530-533. 被引量：4
  • 2FEITELSON M A, SUN B, LIU J, et al. Genetic mechanisms of hepatocarcinogenesis[ J]. Oncogene, 2002, 21 (16) : 2593-2604.
  • 3CHIU CM, YEH SH, CHEN P J, et al. Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level[J]. PNAS, 2007, 104(8) : 2571-2578.
  • 4PISANI P, PARKIN D M, BRAY F, et al. Estimates of the worldwide mortality from 25 cancers in 1990[J]. Int J Cancer, 1999, 83(1): 18-29.
  • 5SU J M, LAI X M, LANK H, et al. X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter[J]. Hepatology, 2007, 46(2) : 402-413.
  • 6BOUCHARD M J, SCHNEIDER R J. The enigmatic X gene of hepatitis B virus[J]. J Virol, 2004, 78(23) : 12725-12734.
  • 7CHEONG J H, YI M, LIN Y, et al. Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation [J]. EMBOJ, 1995, 14(1): 143-150.
  • 8QADRI I, MAGUIRE H F, SIDDIQUI A. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein [ J ]. Proc Natl Acad Sci U S A, 1996, 93 (20) : 10578-10583.
  • 9LIVAK K J, SCHMITTGEN TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method[J]. Methods, 2001, 25(4): 402-408.
  • 10SHIH Y L, SHYU R Y, HSIEH C B, et al. Promoter methylation of the secreted frizzled-related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma[ J ]. Cancer, 2006, 107 (3) : 579-590.

共引文献3

同被引文献140

引证文献9

二级引证文献55

浙江大学学报（医学版）
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部